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pentobarbital will lower the level or effect of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Steer clear of coadministration of lefamulin with potent or moderate CYP3A inducers Except the benefit outweighs risks. Keep track of for decreased efficacy.Contraindicated (one)pentobarbital will